The results indicate that certain types of solid tumors may be intrinsically resistant to infiltration and destruction by tumor-specific T lymphocytes. Our data suggest that such resistance can be disrupted by sub-lethal radiation. The combinatorial approach presented here merits consideration in the design of clinical trials aimed to achieve T cell-mediated anti-tumor immunity.
Stefan Mereiter, Gustav Jonsson, Tiago Oliveira, Johannes Helm, David Hoffmann, Markus Abeln, Ann-Kristin Jochum, Wolfram Jochum, Max J. Kellner, Marek Feith, Vanessa Tkalec, Karolina Wasilewska, Jie Jiao, Lukas Emsenhuber, Felix Holstein, Anna C. Obenauf, Leonardo Lordello, Jean–Yves Scoazec, Guido Guido Kroemer, Laurence Zitvogel, Omar Hasan Ali, Lukas Flatz, Rita Gerardy‐Schahn, Anja Muenster-Kuehnel, Johannes Stadlmann, Josef Penninger
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