STUDY ON VITAMIN B_6 TO REDUCE THE MAIN SIDE EFFECTS OF PRAZIQUANTEL FOR SCHISTOSOMIASIS

Aim To observe the effect of Vitamin B 6 on reduction of the main side effects of Praziquantel for schistosomiasis.Methods Villagers aged 6-60 in 328 endemic villages were selected and divided into experimental and control groups.The experimental group were given single oral dose of both praziquantel and Vitamin B 6,while the control group were given single oral dose of praziquantel and placebo.The dosages of praziquantel were,body weight limit being below 60 kg.45mg /kg for those of 6-14 years old and 40mg/kg for those aged 15-60.Dosages of Vitamin B 6 were 20mg per capita for those of 6-14 years old and 30mg/kg per capita for those aged 15-60.Results Occurrence rate of praziquantel side effects in the experimental group and in the control group were 73 78% and 81 10% respectively,showing significant difference (P0.05).The Occurrence rates of main side effects on the nervous and digestive systems were 72.86% in the experimental group and 79.57% in the control group respectively,also indicating significant difference (P0.05).By contrast of disappearance time of dizziness within 2,4,6,8,and 10 hours,the accumulated disappearance rate of side effects of the experimental group was obviously higher than that of the control group.Conclusion Vitamin B 6 is effective in reducing occurrence rate of the main side effects of Praziquantel for schistosomiasis and speeding up the disappearance time of dizziness.