Structure-Based Design of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent Hiv-1 Nnrtis by Exploiting the Tolerant Regions in Nntris Binding Pocket

Zhenzhen Zhou; Minghui Xie; Zongji Zhuo; Sining Tao; Zhening Liang; De Clercq Erik; Christophe Pannecouque; Peng Zhan; Dongwei Kang; Xinyong Liu

doi:10.2139/ssrn.5073546

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Structure-Based Design of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent Hiv-1 Nnrtis by Exploiting the Tolerant Regions in Nntris Binding Pocket

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Structure-Based Design of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent Hiv-1 Nnrtis by Exploiting the Tolerant Regions in Nntris Binding Pocket

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Discovery of 2,4,6-Trisubstituted Pyrimidine Derivatives as Novel Potent Hiv-1 Nnrtis by Exploiting the Tolerant Region Ii of the Nnibp

Discovery of novel diarypyrimidine derivatives as potent HIV-1 NNRTIs by exploiting the tolerant region I within NNRTI binding pocket