Structural and Functional Brain Network Connectivity at Different King's Stages in Patients With Amyotrophic Lateral Sclerosis — Edoardo Gioele Spinelli (2023) | RDL Network
Structural and Functional Brain Network Connectivity at Different King's Stages in Patients With Amyotrophic Lateral Sclerosis
Article 2023 en
Authors
ES
Edoardo Gioele Spinelli
AG
Alma Ghirelli
SB
Silvia Basaia
Abstract
1 min read
MRI of the brain allows to demonstrate and quantify increasing disruption of structural connectivity involving the sensorimotor networks in ALS, mirroring disease stages. Frontotemporal functional disconnection seems to characterize only advanced disease phases. Our findings support the utility of MRI connectomics to stratify patients and stage brain pathology in ALS in a reproducible way, which may mirror clinical progression.
Federica Agosta, Paola Valsasina, Martina Absinta, Nilo Riva, Stefania Sala, A. Prelle, Massimiliano Copetti, M. Comola, Gıancarlo Comı, Massimo Filippi
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