Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy

Tiago Santos‐Ferreira; Manuela Völkner; Oliver Borsch; Jochen Haas; Peter Cimalla; Praveen Vasudevan; Peter Carmeliet; Denis Corbeil; Stylianos Michalakis; Edmund Koch; Michael Karl; Marius Ader

doi:10.1167/iovs.16-19087

Abstract

1 min read

Comparison of photoreceptor grafts in preclinical models with incomplete or complete photoreceptor loss, showed differential transplant success with effective and impaired integration, respectively. Thus, Cpfl1/Rho-/- mice represent a potential benchmark model resembling patients with severe retinal degeneration to optimize photoreceptor replacement therapies.

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