A general nonlinear model of disease spreading is proposed, describing the effect of the new link-adding probability p in the topological transition of the N-W small-world network model. The new nonlinear model covers both limiting cases of regular lattices and random networks, and presents a more flexible internal nonlinear interaction than a previous model. Hopf bifurcation is proved to exist during disease spreading in all typical cases of regular lattices, small-world networks, and random networks described by this model. It is shown that probability p not only determines the topological transition of the N-W small-world network model, but also dominates the stability of the local equilibria and bifurcating periodic solutions, and moreover can be further applied to stabilize a periodic spreading behaviour onto a stable equilibrium over the network.
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