Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Francesca Castoldi; Guido Guido Kroemer; Federico Pietrocola

doi:10.1080/2162402x.2022.2146855

Abstract

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Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.

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