Spermidine reduces cancer-related mortality in humans

Federico Pietrocola; Francesca Castoldi; Oliver Kepp; Didac Carmona‐Gutiérrez; Frank Madeo; Guido Guido Kroemer

doi:10.1080/15548627.2018.1539592

Abstract

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A recent prospective epidemiological study suggested that an increase in the nutritional uptake of the natural polyamine spermidine is associated with reduced overall and cancer-specific mortality. Here, we speculate through which mechanisms spermidine might exert such oncopreventive effects.Abbreviations: ACLY, ATP citrate lyase; ATG, autophagy-related gene; CoA, coenzyme A; NSCLC, non-small cell lung cancer

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