Special Problems in Treating Tuberculosis

Letters1 March 1994Special Problems in Treating TuberculosisPeter Barnes, MDPeter Barnes, MDUniversity of Southern California School of Medicine; Los Angeles, CA 90033Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-5-199403010-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Salomon, Perlman, and Goldstein present their experience with ofloxacin, ethambutol, and an aminoglycoside in HIV-infected patients with tuberculosis who developed hepatotoxicity while receiving standard antituberculous therapy. My limited experience with this combination therapy in patients with tuberculosis and without HIV infection also suggests that this regimen is adequate to keep the disease under control until the patient can tolerate more standard agents. We agree that additional evaluation of the microbiologic efficacy of this combination is needed.I disagree with Dr. Johnson that corticosteroids should be used liberally in patients with tuberculous pericarditis because of methodologic concerns in ...References1. Strang JI, Gibson DG, Mitchison DA, Girling DJ, Kakaza HH, Allen BW, et al. Controlled clinical trial of complete open surgical drainage and of prednisolone in treatment of tuberculous pericardial effusion in Transkei. Lancet. 1988; 2:759-64. Google Scholar2. Strang JI, Gibson DG, Nunn AJ, Kakaza HH, Girling DJ, Fox W. Controlled trial of prednisone as adjuvant in treatment of tuberculous constrictive pericarditis in Transkei. Lancet. 1987; 2:1418-22. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Southern California School of Medicine; Los Angeles, CA 90033 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1994Volume 120, Issue 5Page: 440-441KeywordsConfidence intervalsDeath ratesHIV infectionsTuberculosis ePublished: 15 August 2000 Issue Published: 1 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...