Solvent-Induced Morphological Transition in Core-Cross-Linked Block Copolymer Micelles

Microwave-assisted polymerization has been utilized to synthesize amphiphilic poly(2-ethyl-2-oxazoline-block-2-"soy alkyl"-2-oxazoline) diblock copolymers (PEtOx-PSoyOx). The amphiphilic block copolymers have been used to prepare aqueous spherical micelles consisting of a PEtOx corona and a PSoyOx core, which have been further cross-linked by UV irradiation. The morphology of these cross-linked micelles has been shown to reversibly change from spheres to short rods referred to as rice grains whenever the micelles were transferred from water into acetone, a nonselective solvent for the constituent blocks. This morphological transition has been attributed to the swelling of the slightly cross-linked PSoyOx core.