Sodium Ascorbate Kills Candida Albicans in Vitro Via Iron-Catalyzed Fenton Reaction: Importance of Oxygenation and Metabolism

Pinar Avci; Fernanda Freire; András Bánvölgyi; Eleftherios Mylonakis; Norbert Wikonkál; Michael R Hamblin

doi:10.2217/fmb-2016-0063

Abstract

1 min read

Ascorbate-mediated killing of C. albicans depends on oxygenation and metabolism, involves iron-catalyzed generation of hydroxyl radicals via Fenton reaction and depletion of intracellular NADH. Ascorbate could serve as a component of a topical antifungal therapy.

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Sodium Ascorbate Kills <i>Candida Albicans in Vitro</i> Via Iron-Catalyzed Fenton Reaction: Importance of Oxygenation and Metabolism

Abstract

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Author response: Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation