Singlet Oxygen Generation via Two-Photon Excited FRET
Article 2004 en
Authors
WD
William R. Dichtel
JS
Jason M. Serin
CE
Carine Edder
Abstract
1 min read
A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.
Michael A. Oar, William R. Dichtel, Jason M. Serin, Jean Mj Frechet, Joy E. Rogers, Jonathan E. Slagle, Paul A. Fleitz, Loon‐Seng Tan, Tymish Y. Ohulchanskyy, Paras N. Prasad
Zheng Zheng, Haixiang Liu, Shaodong Zhai, Haoke Zhang, Guo‐Gang Shan, Ryan T. K. Kwok, Chao Ma, Herman H. Y. Sung, Ian D. Williams, Jacky W. Y. Lam, Kam Sing Wong, Xianglong Hu, Ben Zhong Tang
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