48 patients over 6 years of age with strictly defined cerebral malaria were randomised to receive either a single intramuscular injection of phenobarbitone (3·5 mg/kg) or placebo in a double-blind, placebo-controlled study. Phenobarbitone significantly reduced the incidence of subsequent convulsions from 54% to 12·5%, without adverse effects. A single intramuscular injection of phenobarbitone is a simple, cheap, and effective method for prevention of convulsions in cerebral malaria.
Chi Eziefula, Teun Bousema, Shunmay Yeung, Moses R. Kamya, Asiphas Owaraganise, Grace Gabagaya, John Bradley, Lynn Grignard, Kjerstin Lanke, Humphrey Wanzira, Arthur Mpimbaza, Samuel L. Nsobya, Sir Nicholas White, Emily L. Webb, Sarah G. Staedke, Chris Drakeley
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