The concept of 'optimal medical therapy' relies on recommendations of current consensus-derived guidelines, most of which are supported by 'level of evidence C' (no scientific evidence). 1 However, guidelines recommendations for commonly employed cardiovascular drugs often are based on strong evidence ('level A'). 2 Generally, such drugs are recommended at 'target doses' employed in the trials on which their putative efficacy and regulatory approval are based, and are considered 'optimal medical therapy'. Information about the effectiveness of other doses, lower, or higher, seldom is available.
Roberto Ferrari, Paolo G. Camici, Filippo Crea, Nicolas Danchin, Kim Fox, Aldo Maggioni, Athanasios Manolis, Mario Marzilli, Giuseppe Rosano, José López‐Sendón
Mitchell Robinson, Clare Primiero, Pascale Guitera, Angela Hong, Richard A Scolyer, Jonathan R. Stretch, Geoffrey Strutton, John F. Thompson, H. Peter Soyer
Alan G. Fraser, Rob G. H. H. Nelissen, Per Kjærsgaard‐Andersen, Piotr Szymański, Tom Melvin, Paul Piscoi, Alan G. Fraser, Piotr Szymański, Chris P Gale, Aldo Maggioni, Elisabetta Zanon, Christina Dimopoulou, Cinzia Ceccarelli, Polyxeni Vairami, Anett Ruszanov, Per Kjærsgaard‐Andersen, Rob G. H. H. Nelissen, Adrian Ott, Elizabeth Macintyre, Loredana Simulescu, Marieke Meijer,
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