The murine cell line MH-22A was originally established at least 50 years ago from a non-metastasizing tumor induced by 3-methylcholanthrene in C3HA mice and further adapted for in vitro growth. MH-22A cells grow predominantly epithelioid and they lead to the formation of transplantable tumors when injected subcutaneously into mice. In silico translation of genome data of this nearly triploid cell line to the human genome has recently characterized MH-22A as a suitable model for hepatoblastoma or early hepatocellular carcinoma. Here we established a multi-loci short tandem repeat signature for this cell line that allows quick and reliable cell line authentication.
Ralf Weiskirchen, Jörg Weimer, Steffen K. Meurer, Anja Kron, B. Seipel, Inga Vater, Norbert Arnold, Reiner Siebert, Lieming Xu, Scott L. Friedman, Carsten Bergmann
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