Short Article Regulatory Mutations of mir-48, a C. elegans let-7 Family MicroRNA, Cause Developmental Timing Defects

Ming Li; Matthew W. Jones-Rhoades; Nelson C. Lau; David Bartel; Ann E. Rougvie

Short Article Regulatory Mutations of mir-48, a C. elegans let-7 Family MicroRNA, Cause Developmental Timing Defects

Article 2005 en

Abstract

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Summary The C. elegans heterochronic genes program stagespecific temporal identities in multiple tissues during larval development. These genes include the first two miRNA-encoding genes discovered, lin-4 and let-7 .W e show that lin-58 alleles, identified as lin-4 suppressors, define another miRNA that controls develop

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