Sensitive and Rapid Reversed-Phase Liquid Chromatography–Fluorescence Method for Determining Bisphenol A Diglycidyl Ether in Aqueous–Based Food Simulants

Abstract A method has been developed for determination of bisphenol A diglycidyl ether (BADGE) in 3 aqueous-based food simulants: water, 15% (v/v) ethanol, and 3% (w/v) acetic acid. BADGE is extracted with C18 cartridges and the extract Is concentrated under a stream of nitrogen. BADGE is quantltated by reversed-phase liquid chromatography with fluorescence detection. Relative precision at 200 μg/L was 3.4%, the detection limit of the method was 0.1 μg/L, and recoveries of spiking concentrations from 1 to 8 μg/L were nearly 100%. Relative standard deviations for the method ranged from 3.5 to 5.9%, depending on the identity of the spiked aqueousbased food simulant.