Self-Assembly, Interfacial, and Thermodynamic Properties of Antipsychotic Drug with Bile Salt in Water/Salt Solutions

Abstract Herein, we investigated the micelle formation of mixed systems of the antipsychotic drug, chlorpromazine hydrochloride (CPZ), and the bile salt, sodium deoxycholate (NaDC), both in the absence and presence of NaCl by tensiometry. To understand the aggregation behaviour of the mixture of these two amphiphiles, we calculated various micellar and interfacial parameters using the theories of Clint, Rubingh, Rosen and Motomura. The calculated interaction parameters indicate an attractive interaction between the two amphiphiles both in the absence and presence of salt. The results were discussed with regard to the use of bile salt as a promising drug carrier for CPZ and the improvement of its bioavailability.