Selective V1-agonism and selective V2-antagonism are superior to arginine vasopressin in ovine septic shock

Sebastian Rehberg; Christian Ertmer; BB Pinto; DL Traber; Hugo Van Aken; Fuhong Su; Jean Louis Vincent; M. Westphal

doi:10.1186/cc7347

Abstract

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The present study was designed as a prospective, randomized, laboratory experiment to compare the effects of a selective V1-agonist (Phe2-Orn8-vasotocin), a selective V2-antagonist ((propionyl1-D-Tyr(Et)2-Val4-Abu6-Arg8,9)-vasopressin) and arginine vasopressin (AVP), when given as first-line therapy, on hemodynamics, metabolic changes, mesenteric blood flow (Qma) and mortality using a clinically relevant model of septic shock [1].

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Abstract

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