Selective V1-agonism and selective V2-antagonism are superior to arginine vasopressin in ovine septic shock

The present study was designed as a prospective, randomized, laboratory experiment to compare the effects of a selective V1-agonist (Phe2-Orn8-vasotocin), a selective V2-antagonist ((propionyl1-D-Tyr(Et)2-Val4-Abu6-Arg8,9)-vasopressin) and arginine vasopressin (AVP), when given as first-line therapy, on hemodynamics, metabolic changes, mesenteric blood flow (Qma) and mortality using a clinically relevant model of septic shock [1].