Selective expression and significance of ACKR2 in lung aerocytes
Article 2025 en
Authors
FA
Francesca Albano
VP
Valeria Mollica Poeta
LZ
Lorenza Zotti
Abstract
1 min read
These results indicate that ACKR2 is selectively expressed by lung vascular capillaries (aerocytes) that are devoted to the regulation of leukocyte extravasation. Selective ACKR2 targeting in this compartment, by modulating chemokine availability, promotes T lymphocyte extravasation resulting in reduced lung metastases.
Luciana P. Tavares, Cristiana Couto Garcia, Ana Paula Gonçalves, Lucas Kraemer, Eliza Mathias Melo, Fabrício Marcus Silva Oliveira, Camila S. Freitas, Gabriel Augusto Oliveira Lopes, Diego Carlos dos Reis, Geovanni Dantas Cassali, Alexandre V. Machado, Alberto Mantovani, Massimo Locati, Mauro Martins Teixeira, Remo Castro Russo
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