Selective BRAF Inhibitors Induce Marked T-cell Infiltration into Human Metastatic Melanoma

James S. Wilmott; Georgina V. Long; Julie R. Howle; Lauren E. Haydu; Raghwa Sharma; John F. Thompson; Richard Kefford; Peter Hersey; Richard A Scolyer

doi:10.1158/1078-0432.ccr-11-2479

Abstract

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The increase in tumor-infiltrating lymphocytes induced by treatment with BRAF inhibitors provides strong support for conducting trials that combine BRAF inhibitors with immunotherapy in the hope of prolonging clinical responses.

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Faculty Opinions recommendation of Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.

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