“SECOND GENERATION” OF TSAO COMPOUNDS DIRECTED AGAINST HIV-1 TSAO-RESISTANT STRAINS
Article 2001 en
Authors
EL
Esther Lobatón
SV
Sonsoles Velázquez
MP
María‐Jesús Pérez‐Pérez
Abstract
1 min read
A "second generation" of TSAO molecules directed against TSAO-resistant strains have been prepared. The presence of two neighboring carbonyl groups at the 4" position of the 3'-spiro moiety seems to be important for the anti-HIV-1 activity against both wild type and TSAO-resistant strains. NMR conformational studies in solution and theoretical calculations of the novel compounds have also been carried out.
Sonia de Castro, Esther Lobatón, María‐Jesús Pérez‐Pérez, Ana San‐Félix, Alessandra Cordeiro, Graciela Andreï, Robert Snoeck, De Clercq Erik, Jan Balzarini, Marı́a-José Camarasa, Sonsoles Velázquez
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