SARS-CoV-2 Seroprevalence in Relation to Timing of Symptoms

Joseph E. Ebinger; Gregory J. Botwin; Christine M. Albert; Mona Alotaibi; Moshe Arditi; Anders H. Berg; Aleksandra Binek; Patrick Botting; Justyna Fert‐Bober; Jane C. Figueiredo; Jonathan Grein; Wohaib Hasan; Mir Henglin; Shehnaz K. Hussain; Mohit Jain; Sandy Joung; Michael Karin; Elizabeth H. Kim; Dalin Li; Yunxian Liu; Eric Luong; Dermot McGovern; Akil Merchant; Noah Merin; Peggy B. Miles; Trevor‐Trung Nguyen; Koen Raedschelders; Mohamad Rashid; Céline E. Riera; Richard V. Riggs; Sonia Sharma; Kimia Sobhani; Sarah Sternbach; Nancy Sun; Warren G. Tourtellotte; Jennifer E. Van Eyk; Jonathan Braun; Susan Cheng

doi:10.1101/2020.08.02.20166876

Abstract

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Abstract Of individuals with SARS-CoV-2 IgG antibody testing performed, those who contemporaneously experienced a cluster of Covid-19 relevant symptoms in the 1-2 months preceding the antibody assay were more likely to test positive whereas those who experienced the symptom clustering in the prior 3-6 months were more likely to test negative. These findings suggest that antibodies likely wane over a period of months, particularly in relation to the timing of symptoms.

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