S-Adenosyl-L-homocysteine Hydrolase Inhibitors as Anti-Viral Agents: 5′-Deoxyaristeromycin

Abstract (-)-5′-Deoxyaristeromycin (-)-(3) has been prepared in 13 steps beginning with cyclopentadiene. Compound (-)-3 showed an antiviral activity spectrum characteristic of that of S-adenosyl-L-homocysteine hydrolase inhibitors (such as carbocyclic 3-deazaadenosine and neplanocin A), and, in that regard, (-)-3 was found to possess an IC50 of 3.28 /pm 0.48 μM towards this enzyme.