Role of microsomal prostaglandin E synthase-1 in hippocampal inflammation after repetitive febrile seizures in mouse pups

Yuri Ikeda‐Matsuo; Naruhito Tomori; Yousuke Takemoto; Satoshi Uematsu; Akira Shizuo; Tatsuo Takahashi

doi:10.1254/jpssuppl.96.0_3-b-o07-2

Abstract

1 min read

Febrile seizures (FSs) are the most common convulsive seizure in early childhood. About 30% of them are "complex", with repetitive seizures, and related to adult temporal lobe epilepsy (TLE). In this study, we investigated the role of membrane-associated prostaglandin E synthase-1 (mPGES-1), an inducible terminal enzyme for PGE2 synthesis, in hippocampal inflammation induced by repetitive FSs (RFSs) in mouse pups as a model of complex FSs.

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