Interleukin-6 is a multifunctional cytokine important for host defense. Macrophages are potent producers of interleukin-6. Conversely, interleukin-6 acts on monocytes to induce their differentiation to macrophages. This paper reviews the in vivo roles of interleukin-6 and nuclear factor for interleukin-6 expression that have been revealed by gene targeting as well as recent progress in understanding the interleukin-6 gene regulation and signaling pathway in macrophages.
Dana C. Blok, Miriam H. P. van Lieshout, Arie J. Hoogendijk, Sandrine Florquin, Onno J. de Boer, Cecília Garlanda, Alberto Mantovani, Cornelis van’t Veer, Alex F. de Vos, Tom van der Poll
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