Robust, Reproducible, and Scalable Synthesis of Silver Nanocubes

Abstract It remains a challenge to accomplish colloidal synthesis of noble‐metal nanocrystals marked by high quality, large quantity, and batch‐to‐batch consistency. Here we report a self‐airtight setup for achieving robust, reproducible, and scalable production of Ag nanocubes with uniform and controlled sizes from 18 to 60 nm. Different from the conventional open‐to‐air setup, the self‐airtight system makes it practical to stabilize the reaction condition by minimizing the loss of volatile reagents. The new setup also allows us to easily optimize the amount of O 2 (from air) trapped in the system, ensuring burst nucleation of single‐crystal seeds, followed by their slow growth into nanocubes. Most significantly, the new setup allows for the production of Ag nanocubes at gram quantities without sacrificing uniformity, corner/edge sharpness, controlled size, and high purity across different batches. The availability of high‐quality Ag nanocubes in such a large quantity is anticipated to substantially boost their use in applications related to plasmonics, catalysis, and biomedicine.