Risk of endometrial cancer after use of fertility drugs

cancer diagnosed within the year preceding the interview.Controls included 1787 women residing in the same area, who had been admitted for acute non-neoplastic, non-gynaecological conditions to the same network of hospitals.Two (0.4%) cases and eight (0.4%) controls reported ever use of fertility drugs: the corresponding odds ratio, after allowance for age, education, parity, body mass index, oral contraceptive and hormonal replacement therapy use was 0.8 (95% confidence interval 0.2-4.3).The two cases reporting fertility drug use were treated Ͼ10 years before diagnosis of endometrial cancer.Consequently, our data do not provide meaningful information on the time-risk relation, nor on type of treatment.Despite the low frequency of use, and hence the wide confidence interval, our findings indicate that fertility drugs are not a major risk factor for endometrial cancer in Italy.