RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation

Jerry Wong; Ricard Garcia‐Carbonell; Matija Zelic; Samuel B. Ho; Brigid S. Boland; S. Yao; Shalin A. Desai; Soumita Das; Núria Planell; Philip A. Harris; Joan Font-Burgada; Koji Taniguchi; John Bertin; Azucena Salas; Manolis Pasparakis; Pete J. Gough; Michelle A. Kelliher; Michael Karin; Mónica Gumà

doi:10.1016/j.jcmgh.2019.10.002

Abstract

1 min read

Contrary to common expectations, chronic NF-κB activation induced intestinal crypt apoptosis after TNF stimulation, resulting in severe mucosal erosion. RIPK1 kinase inhibitors selectively inhibited TNF destructive properties while preserving its survival and proliferative properties, which do not require RIPK1 kinase activity. RIPK1 kinase inhibition could be a potential treatment for IBD.

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RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation

Abstract

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Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death

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