Rickettsial Infections and Fever, Vientiane, Laos

Simaly Phongmany; Jean‐Marc Rolain; Rattanaphone Phetsouvanh; Stuart D. Blacksell; Vimone Soukkhaseum; Bouachanh Rasachack; Khamphong Phiasakha; Surn Soukkhaseum; Khamthavi Frichithavong; Vang Chu; Valy Keolouangkhot; Bertrand Martinez-Aussel; Ko Chang; Chirapha Darasavath; Oudayvone Rattanavong; Siho Sisouphone; Mayfong Mayxay; Sisouphane Vidamaly; Philippe Parola; Chanpheng Thammavong; Mayboun Heuangvongsy; Bounkong Syhavong; Didier Raoult; Sir Nicholas White; Paul N. Newton

doi:10.3201/eid1202.050900

Rickettsial Infections and Fever, Vientiane, Laos

Emerging infectious diseases 12(2): 256-262

Article 2006 English

Abstract

1 min read

Rickettsial diseases have not been described previously from Laos, but in a prospective study, acute rickettsial infection was identified as the cause of fever in 115 (27%) of 427 adults with negative blood cultures admitted to Mahosot Hospital in Vientiane, Laos. The organisms identified by serologic analysis were Orientia tsutsugamushi (14.8%), Rickettsia typhi (9.6%), and spotted fever group rickettsia (2.6% [8 R. helvetica, 1 R. felis, 1 R. conorii subsp. indica, and 1 Rickettsia "AT1"]). Patients with murine typhus had a lower frequency of peripheral lymphadenopathy than those with scrub typhus (3% vs. 46%, p<0.001). Rickettsioses are an underrecognized cause of undifferentiated febrile illnesses among adults in Laos. This finding has implications for the local empiric treatment of fever.

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Rickettsial Infections and Fever, Vientiane, Laos

Abstract

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Rickettsial infections are common causes of fever amongst adults in the Lao PDR