Reversed-Phase Chromatographic Properties of Monodispersed Macroporous Particles of Poly(styrene-divinylbenzene) Prepared by a Multi-Step Swelling and Polymerization Method

Abstract Monodispersed macroporous poly(styrene-divinylbenzene) particles in a 5-6 μm size range were prepared by a multi-step swelling and polymerization method with toluene as the porogenic solvent, and their properties were examined. The particles were found to possess relatively broad pore size distributions. HPLC columns packed with the monodispersed particles show good efficiencies and low column pressure drops in a reversed-phase chromatographic mode.