Resisting resistance with PAF receptor antagonists

In Briefobserved in wild-type mice treated with IL-1ra might therefore be caused by a receptorother than IL-1RI in brain. What might thisreceptor be? A search of the human genomereveals an additional seven receptorshomologous to IL-1RI that could becontenders. Only two of these have beenascribed functions: IL-1Rrp1, which is thereceptor for IL-18, and AcPL, the accessoryprotein for this receptor. All the otherreceptors identified are orphans and two ofthem, IL-1RAPL and IL-1Rrp2, have beenshown to be expressed in brain. It is possiblethat they bind IL-1 and elicit the damagingeffects in IL-1RI knockout mice. Whatever thereceptor might be, its identification willallow the possibility of developing agentsthat would block brain damage induced byIL-1, without interfering with other activitiesof IL-1 that are important for host defence.