Repetitive injury causes Alzheimer’s disease‐like phenotypes via reactivation of HSV‐1 in a 3D human brain tissue model

We suggest that after brain injury from repeated mechanical blows in life, the resulting HSV-1 reactivation in the brain leads to the development of AD/dementia, i.e., that HSV-1 is a major cause of AD. We hope to discover ways of alleviating the effects of TBI-induced HSV-1 reactivation that ultimately lead to AD, and whether other types of brain damage cause similar effects.