MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.
Maarten F. Corsten, Anna Papageorgiou, Wouter Verhesen, Paolo Carai, Morten Lindow, Susanna Obad, Georg Summer, Susan L. Coort, Mark R. Hazebroek, Rick van Leeuwen, Marion J. Gijbels, Erwin Wijnands, Erik A.L. Biessen, Menno P.J. de Winther, Frank Stassen, Peter Carmeliet, Sakari Kauppinen, Blanche Schroen, Stéphane Heymans
Bo Wang, Sarmila Majumder, Gerard J. Nuovo, Huban Kutay, Stefano Volinia, Tushar Patel, Thomas D Schmittgen, Carlo M. Croce, Kalpana Ghoshal, Samson T. Jacob
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