Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

Christina M. Lill; Jan Homann; Roxanna Korologou‐Linden; Vivian Viallon; Sarah Morgan; Valerija Dobričić; Laura Deecke; Julia P. Schessner; Karl Smith-Byrne; Daniel Birtles; Yujia Zhao; Joanne Wuu; Fanny Artaud; Fatema Hajizadah; José María Huerta; Olena Ohlei; Mikhail Lebedev; P. Martijn Kolijn; Marcela Guevara; Ana Jiménez-Zabala; María‐José Sánchez; Camino Trobajo‐Sanmartín; Sandra M. Colorado‐Yohar; Sonia Alonso‐Martín; Dafina Petrova; Sabina Sieri; Klaus Berger; Susan Peters; Nicholas J. Wareham; Rudolf Kaaks; Ruth C. Travis; Roel Vermeulen; Ioanna Tzoulaki; Alexis Elbaz; Matthias Mann; Carlotta Sacerdote; Giovanna Masala; Verena Katkze; Michael Benatar; Lars Bertram; Lefkos Middleton; Elio Riboli; Marc Gunter; Oliver Robinson; Pietro Ferrari

doi:10.21203/rs.3.rs-7452736/v1

Preprint2025

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

Jan Homann, Roxanna Korologou‐Linden, Vivian Viallon, Sarah Morgan, Valerija Dobričić, Laura Deecke, Julia P. Schessner, Karl Smith-Byrne, Daniel Birtles, Yujia Zhao, Joanne Wuu, Fanny Artaud, Fatema Hajizadah, José María Huerta, Olena Ohlei, Mikhail Lebedev, P. Martijn Kolijn, Marcela Guevara, Ana Jiménez-Zabala, María José Sánchez, Camino Trobajo‐Sanmartín, Sandra M. Colorado‐Yohar, Sonia Alonso‐Martín, Dafina Petrova, Sabina Sieri, Klaus Berger, Susan Peters, Nicholas J. Wareham, Rudolf Kaaks, Ruth C. Travis, Roel Vermeulen, Ioanna Tzoulaki, Alexis Elbaz, Matthias Mann, Carlotta Sacerdote, Giovanna Masala, Verena Katzke, Michael Benatar, Lars Bertram, Lefkos Middleton, Elio Riboli, Marc J. Gunter, Pietro Ferrari, Oliver Robinson, Christina M. Lill

Preprint2025

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Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

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Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

Redefining ALS: Large-Scale Proteomic Profiling Reveals a Prolonged Pre-Diagnostic&nbsp;Phase with Immune, Muscular, Metabolic, and Brain Involvement

Large‐scale identification of expression quantitative trait loci in <i>Arabidopsis</i> reveals novel candidate regulators of immune responses and other processes

Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling

Brain morphology mediators of the link between childhood trauma and bipolar disorder: a large-scale international analysis

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

Discussion(0)

Open reviews(0)

Related publications

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

Redefining ALS: Large-Scale Proteomic Profiling Reveals a Prolonged Pre-Diagnostic&amp;nbsp;Phase with Immune, Muscular, Metabolic, and Brain Involvement

Large‐scale identification of expression quantitative trait loci in <i>Arabidopsis</i> reveals novel candidate regulators of immune responses and other processes

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Brain morphology mediators of the link between childhood trauma and bipolar disorder: a large-scale international analysis

Redefining ALS: Large-Scale Proteomic Profiling Reveals a Prolonged Pre-Diagnostic Phase with Immune, Muscular, Metabolic, and Brain Involvement