Abstract Fluorescent probes have been widely investigated for their features of rapid response, easy operation and high sensitivity. Among them, reaction‐based fluorescent probes, for their unique reaction‐based nature, guarantee them with excellent selectivity, effectively avoiding the possible interference from other chemical and biological species in physiological environment. Conventional reaction‐based fluorescent probes are aggregation‐caused quenching (ACQ) fluorophores. The application of these kinds of probes are limited for their poor photostability and narrow Stokes shifts. Compared with ACQ fluorophores, aggregation‐induced emission (AIE) fluorophores become emissive in aggregation states with higher signal‐to‐noise ratio, better photostability and larger Stokes shifts. In this review, we summarize the latest developed reaction‐based AIE‐active probes, including the design principle and application in various sensing systems and give an outlook for the future development of this kind of promising fluorescent probes.
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