Randomized Controlled Trial of Levamisole Hydrochloride as Adjunctive Therapy in Severe Falciparum Malaria With High Parasitemia — Richard J. Maude (2013) | RDL Network
Randomized Controlled Trial of Levamisole Hydrochloride as Adjunctive Therapy in Severe Falciparum Malaria With High Parasitemia
The Journal of Infectious Diseases 209(1): 120-129
Article 2013 English
Authors
RM
Richard J. Maude
KS
Kamolrat Silamut
KP
Katherine Plewes
Abstract
1 min read
Background. Cytoadherence and sequestration of erythrocytes containing mature stages of Plasmodium falciparum are central to the pathogenesis of severe malaria. The oral anthelminthic drug levamisole inhibits cytoadherence in vitro and reduces sequestration of late-stage parasites in uncomplicated falciparum malaria treated with quinine.
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