Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor
Article 2011 en
Authors
ZJ
Zhang Ji
LC
Lin Chang
CC
Chunlei Chen
Abstract
1 min read
Our data reveal that Rad deficiency can lead to cardiac fibrosis. Rad inhibits CTGF expression through binding with C/EBP-δ, thus regulating ECM production in the heart. This study suggests a potential link between decreased Rad levels and increased cardiac fibrosis in human failing hearts.
Rafał Pawliński, Aurélia Araújo Fernandes, Bettina Kehrle, Brian Pedersen, Graham C. Parry, Jonathan Erlich, Robert Pyo, David E. Gutstein, Jie Zhang, F.J. Castellino, Els Melis, Peter Carmeliet, G Baretton, Thomas Luther, Mark B. Taubman, Elliot D. Rosen, Nigel Mackman
E. Kovalenko, Frank Tacke, O Gressner, H. Zimmermann, Birgit Lahme, Alfred Janetzko, T. Wiederholt, Thomas Berg, Tobias Müller, Christian Trautwein, Axel M. Gressner, Ralf Weiskirchen
Mahmoud Abdellatif, Viktoria Trummer-Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Sebastian J. Hofer, Moydul Islam, Julia Voglhuber, José M. Ramos Pittol, Oliver Kepp, Gerald Höefler, Albrecht Schmidt, Peter P. Rainer, Douglas S. Scherr, Dirk von Lewinski, Egbert Bisping, Julie R. McMullen, Abhinav Diwan, Tobias Eisenberg, Frank Madeo, Kathrin Thedieck, Guido Guido Kroemer,
Hong Wei, Djahida Bedja, Norimichi Koitabashi, Dongmei Xing, Jasper Chen, Karen Fox-Talbot, Rosanne Rouf, Shaoping Chen, Charles Steenbergen, John W. Harmon, Harry C. Dietz, Kathleen L. Gabrielson, David A. Kass, Gregg L. Friedman
Discussion(0)
No comments yet. Be the first to comment.