We analyze proton decay via dimension-six operators in certain GUT-like models derived from Type IIA orientifolds with D6-branes. The amplitude is parametrically enhanced by a factor of α
GUT
−1/3 relative to the corresponding result in four-dimensional GUTs. Nonetheless, even assuming a plausible enhancement from the threshold corrections, we find little overall enhancement of the proton decay rate from dimension-six operators, so that the predicted lifetime from this mechanism remains close to 1036 years.
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