Prothymosin α and its C-Terminal Immunoreactive DecapeptideShow No Evidence of Acute Toxicity: A Preliminary <i>In Silico</i>, <i>In Vitro</i>and <i>In Vivo</i> Investigation

Our preliminary findings suggest that proTα and proTα(100-109), even at high concentrations, are non-toxic in vitro and in an acute toxicity model in vivo; moreover, we show that the two peptides retain their immunomodulatory properties in vivo and, eventually, could be considered for therapeutic use in humans.