Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours — Ninel Azoitei (2010) | RDL Network
Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours
Article 2010 en
Authors
NA
Ninel Azoitei
GP
Ganesh V. Pusapati
AK
Alexander Kleger
Abstract
1 min read
PKD2 regulates hypoxia-induced VEGF-A expression/secretion by tumour cells and VEGF-A stimulated blood vessel formation. PKD2 is a novel, essential mediator of tumour cell-endothelial cell communication and a promising therapeutic target to inhibit angiogenesis in gastrointestinal cancers.
Ninel Azoitei, Ganesh V. Pusapati, Alexander Kleger, Peter P. Mueller, Rainer Kuefer, Felicitas Genze, Martin Wagner, Johan Van Lint, Peter Carmeliet, G. Adler, T Seufferlein
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