Productive Infection of Primary Macrophages with Human Herpesvirus 7

Ying Zhang; Leen De Bolle; Stefano Aquaro; Alfons Van Lommel; De Clercq Erik; Dominique Schols

doi:10.1128/jvi.75.21.10511-10514.2001

Abstract

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Here we demonstrate replication of human herpesvirus 7 (HHV-7), a T-lymphotropic virus, in macrophages. Productive replication was lost after 2 weeks, but HHV-7 DNA was detected up to 1 month after infection. Thus, macrophages become infected by HHV-7 and might play an important role as a viral reservoir, as has been demonstrated for human immunodeficiency virus type 1.

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