Processing by CD26/dipeptidyl‐peptidase IV reduces the chemotactic and anti‐HIV‐1 activity of stromal‐cell‐derived factor‐1α — Paul Proost (1998) | RDL Network
Processing by CD26/dipeptidyl‐peptidase IV reduces the chemotactic and anti‐HIV‐1 activity of stromal‐cell‐derived factor‐1α
Article 1998 en
Authors
PP
Paul Proost
SS
Sofie Struyf
DS
Dominique Schols
Abstract
1 min read
The chemokine stromal-cell-derived factor-1alpha (SDF-1alpha) chemoattracts lymphocytes and CD34+ haematopoietic progenitors and is the ligand for CXCR4 (CXC chemokine receptor 4), the main co-receptor for T-tropic HIV-1 strains. SDF-1alpha was NH2-terminally cleaved to SDF-1alpha(3-68) by dipeptidyl-peptidase IV (CD26/DPP IV), which is present in blood in soluble and membrane-bound form. SDF-1alpha(3-68) lost both lymphocyte chemotactic and CXCR4-signaling properties. However, SDF-1alpha(3-68) still desensitized the SDF-1alpha(1-68)-induced Ca2+ response. In contrast to CD26/DPP IV-processed RANTES(3-68), SDF-1alpha(3-68) had diminished potency to inhibit HIV-1 infection. Thus, CD26/DPP IV impairs the inflammatory and haematopoietic potency of chemokines but plays a dual role in AIDS.
Paul Proost, Ingrid De Meester, Dominique Schols, Sofie Struyf, Anne‐Marie Lambeir, Anja Wuyts, Ghislain Opdenakker, De Clercq Erik, Simon Scharpé, Jo Van Damme
Sofie Struyf, Paul Proost, Dominique Schols, De Clercq Erik, Ghislain Opdenakker, Jean‐Pierre Lenaerts, Michel Detheux, Marc Parmentier, Ingrid De Meester, Simon Scharpé, Jo Van Damme
Paul Proost, Sofie Struyf, Dominique Schols, Ghislain Opdenakker, Silvano Sozzani, Paola Allavena, Alberto Mantovani, Koen Augustyns, Gunther Bal, Achiel Haemers, Anne‐Marie Lambeir, Simon Scharpé, Jo Van Damme, Ingrid De Meester
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