A double blind study of 44 patients (24 placebo, 20 cimetidine) was undertaken to determine tha effect of cimetidine on the pH and volume of gastric fluid during anaesthesia. The pH was significantly higher on cimetidine-treated patients than placebo-treated patients at 0, 15, 30 and 45 minutes following intubation. At induction of anaesthesia, mean pH on cimetidine was 4.5 and on placebo mean H was 2.0. Approximately 70% of patients on cimetidine and 20% on placebo recorded a pH above 2.5 during anaesthesia. The reason for a pH recording of less than 2.5 in seven patients on cimetidine could not be ascertained. Mean volume of gastric aspirate was slightly lower in the cimetidine group at 0, 15, 30 and 45 minutes, but the differences were not significant.
P. D. Molyneux, Ludwig Kappos, Chris H. Polman, Carlo Pozzilli, Frederik Barkhof, Massimo Filippi, Tarek Yousry, David W. Hahn, Klaus Wagner, Mahdiyeh Khabbaz Koche Ghazi, K. Beckmann, Frank Dahlke, Nicholas Losseff, Gareth J. Barker, Alan J. Thompson, D. H. Miller
Lew Lim, Nazanin Hosseinkhah, Mark Van Buskirk, Andrea Berk, Genane Loheswaran, Zara Abbaspour, Mahta Karimpoor, Alison Smith, Yoke N. Au, Kai F Ho, Abhiram Pushparaj, Michael Zahavi, Alexander White, Jonathan Rubine, Brian Zidel, Christopher Henderson, Russell Gene Clayton, David Roy Tingley, David J. Miller, Mahroo Karimpoor, Michael R Hamblin
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