Changes in 24-h synchronized (circadian) characteristics of blood pressure (BP) and heart rate (HP) are quantified in two consecutive pregnancies of a clinically healthy woman. BP and HR were automatically monitored, with few interruptions, at 1-h intervals, and for a total of 76 days of monitoring in each pregnancy. Circadian parameters of BP and HR were computed for each single day of measurements by the least-squares fit of a 24-h cosine curve. Regression analysis of parameters thus obtained revealed patterns of variation of circadian rhythm-adjusted means and amplitudes with gestational age. This longitudinal study confirms and extends to ambulatory everyday-life conditions the predictable pregnancy-associated variability in BP and HR, and also allows the establishment of prediction and confidence limits for cardiovascular parameters in a healthy pregnancy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
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