Pre-Discharge and Early Post-Discharge Troponin Elevation Among Patients Hospitalized for Heart Failure with Reduced Ejection Fraction: Findings from the ASTRONAUT Trial

In this hospitalized HF population, troponin I elevation was common during index hospitalization and at 1-month follow-up. Elevated troponin I level at 1 month, but not pre-discharge, was independently predictive of increased clinical events at 12 months. Early post-discharge troponin I measurement may offer a practical means of risk stratification and should be investigated as a therapeutic target.