Potentiation of Apoptosis in MDS/AML by Combination of Azacitidine and the EGFR-Tyrosine Kinase Inhibitor (TKI) erlotinib

Élodie Lainey; Marie Sébert; Cyrielle Bouteloup; Carole Leroy; Sylvain Thépot; Maximilien Tailler; Lionel Adès; Claude Gardin; Guido Guido Kroemer; Pierre Fenaux; Simone Boehrer

doi:10.1182/blood.v118.21.2790.2790

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Potentiation of Apoptosis in MDS/AML by Combination of Azacitidine and the EGFR-Tyrosine Kinase Inhibitor (TKI) erlotinib

Discussion(0)

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The EGFR-Inhibitor Erlotinib Induces Differentiation, Cell Cycle Arrest and Apoptosis in EGFR-Negative Cells of MDS and AML.

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Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study