Positive impact of autophagy in human breast cancer cells on local immunosurveillance
Article 2016 en
Authors
SL
Sylvain Ladoire
DE
David Enot
LS
Laura Senovilla
Abstract
1 min read
In human breast cancer cells, the presence of cytoplasmic dots positive for microtubule-associated proteins 1A/1B light chain 3B (LC3B) indicates enhanced autophagic flux and favorable prognosis. LC3B+ puncta within malignant cells positively correlate with the intratumoral abundance of CD8+ cytotoxic T lymphocytes, yet negatively correlate with the frequency of local FOXP3+ regulatory T cells and CD68+ tumor-associated macrophages, resulting in an improvement of CD8+/FOXP+ or CD8+/CD68+ ratios.
Sylvain Ladoire, Laura Senovilla, David Enot, François Ghiringhelli, Vichnou Poirier-Colame, Kariman Chaba, Gulsun Erdag, Jochen T. Schaefer, Donna H. Deacon, Laurence Zitvogel, Craig L. Slingluff, Guido Guido Kroemer
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