Polygenicity of Comorbid Depression in Multiple Sclerosis
Article 2023 en
Authors
KK
Kaarina Kowalec
KF
Kathryn C. Fitzgerald
AS
Amber Salter
Abstract
1 min read
A higher depression genetic burden was associated with approximately 30%-40% increased odds of depression in European genetic ancestry participants with MS compared with those without depression and was no different compared with those with depression and no comorbid immune disease. This study paves the way for further investigations into the possible use of PGS for assessing psychiatric disorder risk in MS and its application to non-European genetic ancestries.
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