Polygenic risk associations with developmental and mental health outcomes in childhood and adolescence: A systematic review

L.B. Moyakhe; Shareefa Dalvie; Mary S. Mufford; Dan Joseph Stein; Nastassja Koen

doi:10.1101/2023.03.31.23287877

Abstract

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The findings of this systematic review suggest that PRS for neurodevelopmental and mental health disorders may associate with adverse neurodevelopmental and mental health outcomes from early childhood to adolescence. In addition, these associations seemed not to be phenotype-specific, suggesting potential shared genetic variation across the phenotypes of interest.

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